羧酸盐
材料科学
金属
超分子化学
配体(生物化学)
纳米团簇
表面改性
金属有机骨架
组合化学
质子化
水溶液中的金属离子
钛
纳米技术
化学
有机化学
分子
离子
物理化学
吸附
受体
冶金
生物化学
作者
Guangyu Chu,Chunlei Zhang,Yifei Liu,Zanxia Cao,Lirui Wang,Yunfeng Chen,Wenjie Zhou,Guo Gao,Kan Wang,Daxiang Cui
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-11-09
卷期号:14 (11): 15633-15645
被引量:42
标识
DOI:10.1021/acsnano.0c06446
摘要
The development of modular strategies for programming self-assembled supramolecular architectures with distinct structural and functional features is of immense scientific interest. We reported on the intrinsic antibacterial capability of anionic amphiphilic gold nanoclusters (GNCs) capped by para-mercaptobenzoic acid, which was closely related to the protonation level of terminal carboxylate groups. By using of the metal–ligand coordination-driven and solvent evaporation-induced self-assembly, we constructed GNCs-based mixed-metal metal–organic network (MM-MON) films on titanium disks as antibacterial nanocoatings. Taking the reasonable utilization of tetravalent metal ions M4+ (Ti, Zr, Hf; hard Lewis acid) and bactericidal divalent metal ions M2+ (Cu, Zn; borderline acid) co-incorporated metal–carboxylate coordination bonds, the MM-MON films exhibited superior stability due to the robust M4+–O bonds and M2+ releasing behavior resulting from the labile M2+–O coordinating. Together, the MM-MON films integrated the bacteria-responsive character of GNCs, exceptional chemical stability, and greatly enhanced antibacterial activity, ultimately killing adherent bacteria and initiating a self-defensive function. In a rat model for subcutaneous implant-associated infection, the MM-MON nanocoating showed an approximately 2 and 1 log lower multidrug-resistant Staphylococcus aureus implant and tissue colonization, respectively. The generalizable modular strategy of the GNC–metal networks is amenable to facilitate the functionalization of metal surfaces for combating implant-associated infections.
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