化学
苯并噻唑
喹唑啉
噻二唑类
蛋白质数据库
立体化学
组合化学
抗菌活性
DNA旋转酶
抗坏血酸
对接(动物)
生物活性
抗氧化剂
邻氨基苯甲酸
质子核磁共振
体外
有机化学
生物化学
大肠杆菌
细菌
护理部
遗传学
食品科学
基因
生物
医学
作者
Ranjit Gadhave,Bhanudas S. Kuchekar
标识
DOI:10.14233/ajchem.2020.22453
摘要
A new series of N-(benzo[d]thiazol-2-yl)-[1,2,4]triazolo[4,3-c]quinazoline-5-carboxamide derivatives were synthesized by condensation of [1,2,4]triazolo[4,3-c]quinazoline-5-carboxylate derivatives with substituted benzothiazoles. The chemical structures of the synthesized compounds were confirmed by FT-IR, MS and 1H NMR spectra. Designed triazoloquinazoline derivatives were docked with oxido-reductase enzyme (PDB Code 4h1j) and DNA gyrase enzyme (PDB Code 3g75). Based on high binding affinity score, the best compound were selected for synthesis and subjected to in vitro antioxidant and antibacterial activity. Compounds 7a and 7d were found to be most active compounds as antioxidant agent among this series when compared with ascorbic acid. Compounds 7a, 7d and 7f were found to be most active compounds as an antibacterial agents among this series when compared with ciprofloxacin against bacterial strains such as S. aureus (ATCC 25923), E. coli (ATCC 25922) and P. aeruginosa (ATCC 27853). Study revealed that the most active compounds after structural modifications can be exploited as lead molecules for other pharmacological activities such as anti-inflammatory, anticancer and antidepressant activities.
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