The anti inflammatory effect of Tie2 signal in vasculitis

Vasculitis is common among children, which is often manifested as Henoch Schonlein purpura (HSP), Kawasaki (KD) disease, systemic lupus erythematosus (SLE), and juvenile idiopathic arthritis (JIA). Inflammation plays a key role in the pathogenesis of vasculitis.It has been found that the activation of tyrosine kinase-2 (Tie2) signaling system can inhibit vascular endothelial cell apoptosis, maintain vascular stability, and reduce vascular leakage, thereby achieving anti-inflammatory effects.Until now, the role of angiopoietins and their receptor Tie2 in inflammatory response is still rare reported.Here we reviews the research about Tie2 signal in vasculitis. Key words: Tyrosine protein kinase-2; Anti-inflammatory; Vascular inflammation; Vascular endothelial protection