S100A8 and S100A9 in dermatoses

S100A8 and S100A9 are important members of the S100 protein family. It was previously deemed that S100A8 and S100A9 participated in inflammatory reactions, were associated with innate immunity, and played key roles in regulating tumor cell generation, infiltration and transformation. However, recent studies have suggested that when the human body is under some special conditions, such as wound healing and ultraviolet irradiation, epithelial cells are induced to secrete both S100A8 and S100A9 proteins, which are also up-regulated in some dermatoses. With further insight into the relationship between S100A8, S100A9 and dermatoses, new strategies will be developed for the diagnosis and treatment of these entities. Key words: Skin diseases; S100 proteins; Calgranulin A; Calgranulin B; Wound healing