清脆的
基因组编辑
转座酶
范围(计算机科学)
计算生物学
生物
重组酶
基因组
Cas9
转录激活物样效应核酸酶
锌指核酸酶
遗传学
转座因子
计算机科学
基因
程序设计语言
重组
作者
Andrew V. Anzalone,Luke W. Koblan,David R. Liu
标识
DOI:10.1038/s41587-020-0561-9
摘要
The development of new CRISPR-Cas genome editing tools continues to drive major advances in the life sciences. Four classes of CRISPR-Cas-derived genome editing agents-nucleases, base editors, transposases/recombinases and prime editors-are currently available for modifying genomes in experimental systems. Some of these agents have also moved rapidly into the clinic. Each tool comes with its own capabilities and limitations, and major efforts have broadened their editing capabilities, expanded their targeting scope and improved editing specificity. We analyze key considerations when choosing genome editing agents and identify opportunities for future improvements and applications in basic research and therapeutics.
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