Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens

Dactylicapnosines A ( 1 ) and B ( 2 ), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro . Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo .