前列腺素
家族性腺瘤性息肉病
腺瘤
医学
结直肠癌
发病机制
内科学
胃肠病学
环氧合酶
苏林达克
前列腺素
前列腺素E2
非甾体
内分泌学
癌症
酶
生物
生物化学
作者
Vincent W. Yang,Janiel M. Shields,Stanley R. Hamilton,Ernst W. Spannhake,Walter C. Hubbard,Linda M. Hylind,C. Rahj Robinson,Francis M. Giardiello
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:1998-04-15
卷期号:58 (8): 1750-3
被引量:53
摘要
Recent studies indicate that nonsteroidal anti-inflammatory drugs have a chemopreventive effect against colorectal neoplasia. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenases, principal enzymes that mediate the formation of prostanoids. To determine whether prostanoids are involved in the pathogenesis of colorectal adenomas, we compared the levels of five major stable metabolic products of the cyclooxygenase pathway in the normal-appearing mucosa and in adenomas of patients with familial adenomatosis polyposis. Of 12 patients tested, 6 had elevated levels of at least one prostanoid in the adenomas. More importantly, the relative levels of three prostanoids [prostaglandin (PG)D2, PGE2, and 6-keto-PGF1alpha] were elevated in adenomas compared to normal-appearing mucosa from the same patients, and the resulting ratios were correlated with the size of the adenoma. These results suggest a role for prostanoids in progression of colorectal polyposis in familial adenomatosis polyposis patients.
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