The Proteasome as a Drug Target

This chapter contains sections titled: Introduction The Ubiquitin-Proteasome System Role of the Ubiquitin-Proteasome System 26S Proteasome 20S Proteasome Structure of the 20S Proteasome Active Sites of Eukaryotic 20S Proteasomes Novel Ntn-Hydrolase Active Site of the β7 Subunit Predicted Structure of Immunoproteasome and Substrate Specificities Proteasome Inhibitors Structure of Proteasome Inhibitor Complexes Conclusions