心肌梗塞
医学
重症监护医学
心力衰竭
临床试验
梗塞
心脏病学
疾病
内科学
作者
Demin Li,Kui Tian,Jiacheng Guo,Qiguang Wang,Zhen Qin,Yongzheng Lu,Yanyan Xu,Nicola Scott,Chris J Charles,Guozhen Liu,Jinying Zhang,Xiaolin Cui,Jiyu Tang
出处
期刊:Regenerative Medicine
[Future Medicine]
日期:2022-08-01
卷期号:17 (8): 561-579
被引量:2
标识
DOI:10.2217/rme-2022-0007
摘要
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Despite recent advances in clinical management, reoccurence of heart failure after AMI remains high, in part because of the limited capacity of cardiac tissue to repair after AMI-induced cell death. Growth factor-based therapy has emerged as an alternative AMI treatment strategy. Understanding the underlying mechanisms of growth factor cardioprotective and regenerative actions is important. This review focuses on the function of different growth factors at each stage of the cardiac repair process. Recent evidence for growth factor therapy in preclinical and clinical trials is included. Finally, different delivery strategies are reviewed with a view to providing workable strategies for clinical translation.Acute myocardial infarction is a serious, life-threatening disease. Current treatments for acute myocardial infarction are unsatisfactory, and new treatments are required. Growth factors are promising treatments for myocardial infarction. It is intriguing to understand how growth factors provide cardioprotective benefits. This article describes the various growth factors used to treat myocardial infarction and how they are delivered to the infarcted heart.
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