Synthetic Strategies Towards the Meroterpenoids Cochlearols A and B from Ganoderma cochlear

Abstract Since the first reports of their isolation, the meroterpenoids cochlearol A and B have attracted interest from the synthetic community for their unique structural features. This review describes the attempted and successful total syntheses of these natural products and provides a summary of the strategies developed in the years since their isolation. 1 Introduction 2 Overview of Cochlearol A Syntheses 3 Tong’s Approach Towards Cochlearol A 4 Liu and Qin’s Total Synthesis of (±)-Cochlearol A 5 Ishigami’s Formal Synthesis of (±)-Cochlearol A 6 Chandrasekhar’s Formal Synthesis of (±)-Cochlearol A 7 Sugita’s Synthesis of (±)-Cochlearol B 8 Schindler’s Synthesis of (+)-Cochlearol B 9 Conclusions