精氨酸酶
肿瘤微环境
鸟氨酸
免疫系统
癌症研究
癌症
精氨酸
基因亚型
尿素循环
生物
化学
生物化学
免疫学
遗传学
基因
氨基酸
作者
Fanglin Niu,Yi Yu,Zhuozhuo Li,Yuanyuan Ren,Zi Li,Qiang Ye,Ping Liu,Chenshuang Ji,Qian Lü,Yuyan Xiong
标识
DOI:10.1016/j.biopha.2022.112840
摘要
Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-ornithine. Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in various types of cancers, and played crucial roles in the regulation of tumor growth and metastasis through various mechanisms such as regulating L-arginine metabolism, influencing tumor immune microenvironment, etc. Thus, arginase receives increasing focus as an attractive target for cancer therapy. In this review, we provide a comprehensive overview of the physiological and biological roles of arginase in a variety of cancers, and shed light on the underlying mechanisms of arginase mediating cancer cells growth and development, as well as summarize the recent clinical research advances of targeting arginase for cancer therapy.
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