Remote Alkenylation via Carbopalladation/1,4‐Palladium Migration/Heck Reaction Sequence with Unactivated Alkenyl Alcohols

Abstract Intramolecular C−H bond activation via 1,4‐palladium migration has become a synthetic tool to enable remote functionalization of C−H bonds. In this work, we report a Pd‐catalyzed remote alkenylation with unactivated alkenyl alcohols involving a 1,4‐palladium migration step. This method provides a regioselective access to synthesize substituted unsaturated alcohols in a single operational step. magnified image