Tumor-Associated High Endothelial Venules: Inroads Enabling Immune Control of Cancer Progression
高内皮静脉
免疫系统
免疫学
病理
医学
生物
作者
Awen Gallimore
出处
期刊:Cancer immunology research [American Association for Cancer Research] 日期:2022-04-01卷期号:10 (4): 371-371
标识
DOI:10.1158/2326-6066.cir-22-0112
摘要
Infiltration of lymphocytes into solid tumors represents a significant bottleneck to successful control of tumor growth. The nature of tumor blood vessels is an important factor governing both quantitative and qualitative features of the immune infiltrate. In this issue, Sawada and colleagues identify a genetic signature for blood vessels, most notably high endothelial venules, which are associated with tertiary lymphoid structures and improved clinical outcome. See related article by Sawada et al., p. 468 (4).