蛋白尿
医学
内科学
脂肪肝
脉冲波速
优势比
2型糖尿病
腰围
糖尿病
体质指数
胃肠病学
心脏病学
疾病
内分泌学
血压
作者
Jialu Wang,Shanshan Liu,Qiuyu Cao,Shujing Wu,Jingya Niu,Ruizhi Zheng,Lizhan Bie,Zhuojun Xin,Yuanyue Zhu,Shuangyuan Wang,Hong Lin,Tiange Wang,Min Xu,Jieli Lu,Yuhong Chen,Yawei Xu,Weiqing Wang,Guang Ning,Yu Xu,Mian Li,Yufang Bi,Zhiyun Zhao
标识
DOI:10.1007/s11684-021-0888-8
摘要
A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposed. We aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liver disease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuria in a community-based study sample in Shanghai, China. After 4.3 years of follow-up, 778 participants developed elevated baPWV and 499 developed albuminuria. In comparison with the non-MAFLD group, the multivariable adjusted odds ratio (OR) of MAFLD group for new-onset elevated baPWV was 1.25 (95% confidence interval (CI) 1.01–1.55) and 1.35 (95% CI 1.07–1.70) for albuminuria. Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria (OR 1.77; 95% CI 1.07–2.94). Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria. In conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index, waist circumference, and hip circumference. Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria, supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI