Catalyst‐ and Oxidant‐Free Desulfonative C−P Couplings for the Synthesis of Phosphine Oxides and Phosphonates

Abstract An efficient and practical approach towards phosphine oxides and phosphonates has been successfully developed through the desulfonative coupling of various sulfones with secondary phosphine oxides and phosphites. This protocol features simple experimental procedures under mild conditions (i. e., catalyst‐ and oxidant‐free, room temperature and open to air). By doing so, a variety of alkynyl, alkenyl and allyl phosphine oxides or phosphonates can be produced in generally good reaction efficiency and selectivity (31 examples, up to 98% yield). magnified image