生物安全
间充质干细胞
归巢(生物学)
生物技术
免疫原性
转基因生物
干细胞
生物
免疫系统
免疫学
细胞生物学
遗传学
生态学
基因
作者
Kar Wey Yong,Jane Ru Choi,Asdani Saifullah Dolbashid,Wan Kamarul Zaman Wan Safwani
出处
期刊:Regenerative Medicine
[Future Medicine]
日期:2018-03-01
卷期号:13 (2): 219-232
被引量:28
标识
DOI:10.2217/rme-2017-0078
摘要
An outstanding amount of resources has been used in research on manipulation of human stem cells, especially mesenchymal stem cells (MSCs), for various clinical applications. However, human MSCs have not been fully utilized in clinical applications due to restrictions with regard to their certain biosafety and bioefficacy concerns, for example, genetic abnormality, tumor formation, induction of host immune response and failure of homing and engraftment. This review summarizes the biosafety and bioefficacy assessment of human MSCs in terms of genetic stability, tumorigenicity, immunogenicity, homing and engraftment. The strategies used to reduce the biosafety concerns and improve the bioefficacy of human MSCs are highlighted. In addition, the approaches that can be implemented to improve their biosafety and bioefficacy assessment are briefly discussed.
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