强直性脊柱炎
炎症
发病机制
免疫系统
免疫学
获得性免疫系统
医学
先天免疫系统
疾病
脊柱炎
病理
作者
Alireza Rezaiemanesh,Mohsen Abdolmaleki,Kamal Abdolmohammadi,Hamideh Aghaei,Fatemeh Dadgar Pakdel,Yousef Fatahi,Narjes Soleimanifar,Mahdi Zavvar,Mohammad Hossein Nicknam
标识
DOI:10.1016/j.biopha.2018.01.108
摘要
Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS.
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