趋化因子
趋化性
单核细胞
生物
炎症
CCL7型
细胞生物学
免疫系统
CCR3
趋化因子受体
免疫学
巨噬细胞炎性蛋白
受体
糖基化
生物化学
作者
Patricia Menten,Anja Wuyts,Jozef Van Damme
出处
期刊:PubMed
日期:2002-01-10
卷期号:12 (4): 554-60
被引量:29
摘要
Monocyte chemotactic protein-3 (MCP-3) belongs to the MCP subgroup of CC chemokines that are structurally closely related but, which differ in receptor usage and hence in biological activities. MCP-3 is one of the most pluripotent chemokines since it activates all types of leukocytes, by binding to at least four different chemokine receptors. The natural protein is heterogeneous due to glycosylation and NH2-terminal processing. Only small amounts of MCP-3 are induced in various cell types by endogeneous (cytokines) or exogeneous (bacteria, viruses) agents. Nevertheless, this omnipotent chemokine, inducible in most body compartments, might play an important role in normal homeostasis as well as in various pathologies including cancer, auto-immune diseases and chronic inflammation.
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