化学
芳基
胺化
位阻效应
烷基
催化作用
药物化学
基础(拓扑)
草酸
有机化学
组合化学
数学
数学分析
作者
Wei Zhou,Mengyang Fan,Jun Yin,Yongwen Jiang,Dawei Ma
摘要
A class of oxalic diamides are found to be effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)aryl chlorides. The reaction proceeds at 120 °C with K3PO4 as the base in DMSO to afford a wide range of (hetero)aryl amines in good to excellent yields. The bis(N-aryl) substituted oxalamides are superior ligands to N-aryl-N′-alkyl substituted or bis(N-alkyl) substituted oxalamides. Both the electronic nature and the steric property of the aromatic rings in ligands are important for their efficiency.
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