系统性红斑狼疮
CD19
医学
B细胞
免疫学
癌症研究
抗体
抗原
内科学
疾病
作者
Rita G. Kansal,Noah Richardson,Indira Neeli,Saleem Khawaja,Damian Chamberlain,Marium Ghani,Qurat-ul-ain Ghani,Louisa Balázs,Šárka Beranová-Giorgianni,Francesco Giorgianni,James N. Kochenderfer,Tony N. Marion,Lorraine M. Albritton,Marko Radic
标识
DOI：10.1126/scitranslmed.aav1648
摘要
B cells and reduced disease in naive autoimmune mice, indicating that disease control was cell-mediated. Sustained B cell depletion with CD19-targeted CAR T cell immunotherapy is a stable and effective strategy to treat murine lupus, and its effectiveness should be explored in clinical trials for lupus.
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(2025-6-4)
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