免疫系统
病态的
甲状腺癌
病理
医学
CD8型
免疫组织化学
甲状腺
生物
癌症研究
免疫学
内科学
作者
Casey Means,Daniel Clayburgh,Lauren Maloney,David Sauer,Matthew H. Taylor,Maisie L. Shindo,Lisa M. Coussens,Takahiro Tsujikawa
出处
期刊:Head & neck
[Wiley]
日期:2019-03-21
卷期号:41 (8): 2636-2646
被引量:19
摘要
Abstract Background Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to 30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune complexity may provide new biomarkers for improved risk prediction. Methods Immune complexity profiles were quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 39 patients with PTC, and were assessed for correlations with aggressive histopathological features based on the presence of lymphovascular invasion and/or extrathyroidal extension, and BRAF V600E mutational status. Results mIHC revealed two distinct immune clusters stratifying patients: a lymphoid‐inflamed group (higher CD8 + T cells, reduced dendritic and mast cells) and a myeloid/hypo‐inflamed group that correlated with aggressive pathological features. BRAF mutation was not associated with aggressive pathological features but did correlate with increased mast cell density. Conclusions Distinct immune microenvironments exist in PTC correlating with pathological aggressiveness. Immune‐based biomarkers associated with possible tumor‐immune interactions may be used for risk stratification.
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