Lactobacillus reuteri improves gut barrier function and affects diurnal variation of the gut microbiota in mice fed a high-fat diet

Lactobacillus reuteri FN041 prevented HFD induced over weight gain, fat accumulation, endotoxaemia and mucosal-barrier damage, which is related to modulation of diurnal variation of serum lipid, hepatic Fas gene expression, diversity and metabolic activity of gut microbiota.