Construction of Optically Active 2H‐ and 3H‐Pyrroles by Cyclization and Chirality Maintaining 1,5‐Ester Shift Reactions

Abstract Construction of enantioenriched 2 H ‐ and 3 H ‐pyrroles are achieved in current work by using readily available α‐isocyanoacetates and alkynyl ketones as precursors. To realize the asymmetric synthesis of 2 H ‐pyrroles, a proper in situ generated magnesium catalytic method was developed. On the other hand, the discovery of an aluminium mediated chirality maintaining 1,5 ‐ester shift reaction promoted the successful synthesis of enantioenriched 3 H ‐pyrroles. magnified image