裂谷1
激酶
炎症
信号转导
细胞生物学
生物
发病机制
免疫系统
免疫学
免疫
坏死性下垂
细胞凋亡
程序性细胞死亡
遗传学
作者
Sudan He,Xiaodong Wang
标识
DOI:10.1038/s41590-018-0188-x
摘要
Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating intracellular inflammatory signaling pathways or by causing apoptotic or necrotic cell death. In this Review, we discuss the signaling pathways and immunological functions of these RIP kinases in the inflammatory response to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.
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