Effects of perfluorocarbon aerosol inhalation on the lung surfactant and surfactant-related protein A and TNF-α in rats with acute lung injury

Objective To investigate the effects of perfluorocarbon(PFC) aerosol inhalation on lung surfactant,surfactant-related protein A(SP-A) and tumor necrosis factor(TNF)-α in rats with acute lung injury(ALI).Methods ALI in group A was induced by intraperitoneal injection of lipopolysaccharide(LPS) and intervened with PFC.SP-A,TNF-α and lung surfactant concentration in bronchoalveolar lavage fluid(BALF) were measured.The results were compared with those in group B,in which normal saline was used instead of LPS as the control.Results Compared with group B,PFC aerosol inhalation in group A significantly reduced death incidence with the increases in SP-A and lung surfactant levels,but a decrease in TNF-α concentration in the BALF(P0.01).ConclusionPFC inhalation increases the survival rate of ALI rats by increasing SP-A and lung surfactant and decreasing TNF-α of BALF.