Objective: To investigate the trends and the characteristics of proteinuria in 376 patients with subtertian malaria. Methods: The complete clinical information of 376 patients with subtertian malaria was collected and the data concerning proteinuria were analysed and compared statistically. Results: 28.19% of the patients had +- proteinuria; 23.67% percent had + proteinuria; 8.24% had ++ proteinuria; 1.60% had +++ proteinuria. Proteinuria usually occurred on the 2nd day after the onset of subtertian malaria. Proteinuria would decrease or vanish in most patients within a week after the disease had been controlled. Proteinuria occurred more commonly in patients with high fever of more than 39 ℃. Conclusion: Subtertian malaria usually causes functional proteinuria and the prognosis is usually good. Individual differences, fever grade, deposition of immune complexes and prompt cure are associated with positive proteinuria.