Analysis of human papillomavirus infection in women in Hezhou city

Objective To analyze the genotype and age distribution of human papillomavirus(HPV) infection in women in Hezhou city, providing data for the import, research and development of HPV prophylactic vaccines.Methods Polymerase chain reaction(PCR) and DNAreveres dot blot hybridization technology were used. The testing results of gene subtypes of 2 092 cervical secretion samples were retrospectively analyzed in order to know the HPV infection of local women. These samples were divided into five groups according to ages: 16~25 group, 26~35group, 36~45 group, 46~55 group and 55 group, respectively. The characteristics of infection among five groups were compared. Results There were 590 positive samples(the positive rate was 28.2%) and the three main genotypes were HPV16, 58 and 52. The positive rates of five groups were 66.9%, 23.0%, 23.0%, 30.0% and 28.9% respectively.Most patients were infected with a single type of HPV(75%). Patients infected with two or more genotypes of HPVs in five groups were 43.4%, 19.9%, 18.9%, 22.1% and 21.6% respectively. Conclusion The main HPV subtypes in women in Hezhou city are HPV16, 58, 52 and there are differences in the distribution of HPV subtypes among the five groups. Teens are high-risk of HPV infection in Hezhou and it is necessary for them to receive HPV vaccine.