Analysis of chemotherapy effect on apoptosis and prognosis of osteosarcoma

Objective To study the chemotherapy effect of apoptosis of osteosarcoma and its relationship with prognosis.Methods The survival rate and the rate of lung metastasis were compared between chemotherapy group and none-chemotherapy group by retrospective study on 53 osteosarcoma samples in human,and apoptotic body and expression of cyclin D1 in osteosarcoma were detected by using histological observation and immuneohistochemistry (SP).Results The 3 years and 5 years survival rates and apoptosis rate of chemotherapy group were apparently higher than those of none-chemotherapy group (P0.05);the rate of lung metastasis and positive rate of cyclinD1 of chemotherapy group were significantly lower than those of none-chemotherapy group (P0.05);The apoptosis rate has positive correlation with the 3 years and 5 years survival rate.Conclusions Chemotherapy can increase survival rate of osteosarcoma significantly;The chemotherapy effect obtained mainly by inducing apoptosis and suppressing cell proliferation;Apoptosis rate of tumor is an important factor that influences the prognosis of osteosarcoma.