Expression of TGF-β1 TGF-βR IIand Smad4 in u-veal melanoma

Objective To investigate the expression of TGF-β1 /TGF-βR Ⅱ and Smad4 in uveal melanoma and the possible mechanisms by which they affect uveal melanoma. Methods Immunohistochemical technique was used to detect the expression of TGF-β1/TGF-(βR Ⅱ and Smad4 in 24 cases of paraffin enbeded uveal melanoma samples,and the positive rate was calculated and analyzed. Results In all the 24 cases of uveal melanoma specimens, TGF-β1 is positively expressed in 24/24 tumor tissues ;TGF-βRⅡ is positive in 12/24 cases, and Smad4 is found positive in 11/24 cases,there are 5 cases expressing both TGF-βRⅡ and Smad4.Conclusion The expression of TGF-βl is found higher in uveal melanoma than normal uvea of para-melanoma; the abnormal expression of TGF-βR22222 and Samd 4 may relate to the cause of uveal melanoma.