Objective To analyze 16 slice spiral CT(MSCT)associated lung volume,density index and the index of pulmonary ventilation function,discusses MSCT and pulmonary function test(PFT)index relationship.Methods 64 subjects underwent chest MSCT scan and PFT.Lung density index under different respiratory phase MSCT study:deep inspiratory mean lung density(MLDin),deep end expiratory lung density(MLDex)and mean lung density difference(MLDex-MLDin).PFT observation of pulmonary function indexes including total lung capacity(TLC),residual volume(RV),residual volume and total lung capacity ratio(RV/TLC),forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and forced expiratory volume in one second and forced vital capacity ratio(FEV1/FVC).Results On the basis of CT emphysema diagnosis standard,64 subjects can be divided into MSCT emphysema group 40 cases and MSCT 24 cases of normal group.On the basis of PFT emphysema diagnosis standard,they can be divided into PFT emphysema group 38 cases and PFT normal group26 cases.A different degree of positive correlation of MSCT lung volume index and pulmonary function indices(P0.05),correlation between Vin,Vex and PFT absolute index of static lung volume index of TLC,RV higher than the pulmonary function indices FVC,FEV1.MSCT was negatively related to lung density index(P0.05) and PFT static lung volume index,were positively correlated with the pulmonary function indices(P0.05).Conclusion MSCT lung volume and density index and PFT index of pulmonary ventilation function have good correlation.MSCT detection can better judge of pulmonary function in patients,with good clinical application value.