Overview of Current Researches on Pathogenetic Mechanisms of Diabetic Nephropathy

Diabetic nephropathies(DN) is the most common chronic complications of diabetes mellitus(DM),and is the leading cause of end-stage renal disease(ESRD) either.There are a lot of pathogentic mechanisms can contribute to the development of the diaease,such as sugar metabolism disorders,hemodynamic dysfunctions,lipid metabolism disorders,cytokines,oxidatives stress mechanisms and genetic susceptibility etc.These pathogentic mechanisms will be overviewed as follows.