Immunomodulator,immunosuppression of radiation and immune reconstruction

There is a refined and complicated regulatory network between immune cells,and between immune cells and secretory factors.The immune system is kept in a homeostasis and equilibrium by positive activation and negative inhibition.In recent years,the mechanisms of immunosuppression in depth for successful allograft transplantation were studied,and many immunosuppressants and immunosuppressive drugs have been developed for clinical use.Most of them are targeting T cell receptors and three kinds of singnal pathways.The receptors of the immunosuppression were either found highly expressed in immune cells after irradiation.To relieve the suppression by regulating the receptors could help the immune reconstruction out of radiation damage.Many new immunoenhancers have been discovered to improve the immune system function for radiation by Toll-like receptors.The search for new immunoenhancers and agents for relieving immunosuppression is of great importance to immune construction for radiation sickness.