The development of molecule-targeted therapy is a major breakthrough in the treatment of cancer.Compared with radiotherapy and chemotherapy,molecule-targeted therapy perform an important role in individually tailored cancer therapy because of the lower toxicity and higher efficiency.Over the recent 15years,the emergence of molecule-targeted therapy has brought great change to treatment of cancer,and also brought challenges to clinician.The timing of using the molecular-targeted therapy has become a heatedly-discussed issue.This review illustrated the issue from the perspective of molecular targeted therapies which were recommended for the cure of non small cell lung cancer,breast cancer,malignancies in digestive system and kidney cancer.