Hemostatic effects of three types of hemostatic agents on hepatic trauma in rabbits

Objective To study the hemostatic effects of topical hemostatic agents: gelatin fleece (GF),oxidized cellulose (OC) and gelfoam (GL) on hepatic trauma in rabbits,and histological changes induced by 3 topical hemostatic agents.Methods Three types of hemostatic agent were used in a uniform model of hepatic trauma of rabbit. The blood loss and time to hemostasis were accurately recorded. The materials were left in situ and animals were killed between 1 day and 8 weeks later to examine speed of absorption and histological changes of hemostatic agents.Results GF stopped bleeding more rapidly than GL or OC,and was absorbed almost completely at 8 weeks,with little histological changes.ConclusionGF is an absorbable material with better hemostatic effects and little histological changes.