Experimental study on anti-nociceptive effects of alcohol extracts of LS

Objective To observe anti-nociceptive effects of LS on several pain models.To explore its potential anti-nociceptive pain site and its possible mechanisms.To analyze and compare the similarities and differences between LS and Dolantin.Methods The anti-nociceptive pain effects of LS on animals were observed with mice hotplate test,mice writhing test,mice tail-contracting test with light-hot stimulusResults Mice hotplate latency were prolonged remarkable-ly.Compared with those induced by dolantin,the anti-nociception effects of LS started slowly but lasted a long time and LS exerted definite anti-nociceptive effects by inhibiting mice writhing,mice tail-contracting latency and rats tail-flicking latency.Conclusion LS would have definite anti-nociceptive.