A new kind of coronary artery stent made of 316L stainless steel was designed and processed by using laser cutting and electrochemical polishing which was used to remove the sharp corner of the stent caused by the laser cutting. The influence of process techniques on biocompatibility of the stent was also studied through the cell culture experiments with 3T3 cell and rat medullary cell and hemolysis tests.The results of comparative experiments showed that the shapes and quantities of the cells with stent were the same as those of cells with no stent, which means that the activities of the cells were not affected by the stent.The results also showed that the stent couldn′t cause hemolysis effect. The process techniques of the coronary artery stent were reasonable and free of biologic toxicity.