The relationship on dendritic cells and HIV-1 immunotherapy

Ag targeting and activation of APCs,especially dendritic cells(DCs),are important in vaccine development.DCs have profound abilities to induce and sustain Ag-specific T cell responses.Current clinical trials show that DCs immunotherapy is safe and efficacious in HIV-infected patients.This paper mainly reviews the differentiation,migration,maturation of DCs and effect of DCs immunotherapy of HIV infection,types of antigen and clinical trials of DCs immunotherapy.