Clinical observation of chemotherapy of Capecitabine combined with Oxaliplatin in treatment of advanced gastric cancer

Objective To observe the efficacy and toxicity of the chemotherapy of Capecitabine combined with Oxaliplatin in treatment of patients with advanced gastric cancer.Methods 50 patients with advanced gastric cancer were randomly divided into group A and group B,with 25 cases respectively.Group A: Capecitabine 1 000 mg/m2,po,bid,d1-14;Oxaliplatin 130 mg/m2,ivgtt(2 h),d1;Group B: Leucovorin 200 mg/d,ivgtt(2 h),d1~5;Fluorouracil 750 mg/d,ivgtt(8 h),d1-5;Oxaliplatin 130 mg/m2,ivgtt(2 h),d1.They were repeated every 3 weeks.Results The differences in clinical efficacy were not obvious between the two groups(P 0.05).The toxicity of digestive systemtoxicity in group A was obviously milder than the toxicity in group B(P 0.01).Conclusion The chemotherapy of Capecitabine combined with Oxaliplatin is worthwhile to be applied widely in treatment of patients with advanced gastric cancer.