炎症
纤维细胞
纤维化
先天性淋巴细胞
细胞外基质
医学
先天免疫系统
间充质干细胞
免疫学
免疫系统
细胞生物学
获得性免疫系统
病理
生物
癌症研究
出处
期刊:Matrix Biology
[Elsevier]
日期:2018-08-01
卷期号:68-69: 106-121
被引量:346
标识
DOI:10.1016/j.matbio.2017.11.010
摘要
Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue damage not only induces inflammation in general, it also determines the type and polarization of inflammation by recruiting and activating a variety of different cells types of the innate and adaptive immune system. This review focuses on the pathways leading from tissue damage to inflammation, from inflammation to fibrosis and from fibrosis to function. It covers the pro- and antifibrotic properties of immunological mediators released from T cells, monocytes/macrophages, innate lymphoid cells, basophils and eosinophils and takes into account that extracellular matrix proteins are not only produced by mesenchymal fibroblasts but also by other cell types, especially infiltrating hematopoietic cells. The special requirements for activation and recruitment of these so called fibrocytes are described in detail.
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