High‐Pressure‐Promoted Multicomponent and Metal‐Free Synthesis of Polyfunctionalized Biaryls

An efficient and metal‐free synthesis of biaryls and heterobiaryls has been developed through a key three‐component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 °C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal‐uncontamined 1,1′‐biaryls and heterobiaryls in an energy‐ and step‐economic fashion.