生物
神经科学
肿瘤微环境
癌症
癌症干细胞
前列腺癌
干细胞
癌细胞
细胞生物学
神经干细胞
遗传学
作者
Humsa S. Venkatesh,Michelle Monje
标识
DOI:10.1016/j.trecan.2016.12.008
摘要
The nervous system plays a central role in regulating the stem cell niche in many organs, and thereby pivotally modulates development, homeostasis, and plasticity. A similarly powerful role for neural regulation of the cancer microenvironment is emerging. Neurons promote the growth of cancers of the brain, skin, prostate, pancreas, and stomach. Parallel mechanisms shared in development and cancer suggest that neural modulation of the tumor microenvironment may prove a universal theme, although the mechanistic details of such modulation remain to be discovered for many malignancies. We review here what is known about the influences of active neurons on stem cell and cancer microenvironments across a broad range of tissues, and we discuss emerging principles of neural regulation of development and cancer.
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