医学
蛋白尿
微量白蛋白尿
糖尿病肾病
肌酐
泌尿科
肾活检
内科学
透析
肾病
糖尿病
肾
血液透析
肾移植
活检
胃肠病学
肾功能
内分泌学
出处
期刊:PubMed
日期:2022-11-01
卷期号:26 (21): 7892-7898
标识
DOI:10.26355/eurrev_202211_30140
摘要
We aimed at investigating the effect of non-albumin proteinuria on renal outcomes in patients with biopsy-proven diabetic nephropathy.The files of all patients who underwent kidney biopsy between January 2010 and January 2020 were reviewed retrospectively. Non-albumin proteinuria was calculated by subtracting albumin from total protein in 24-hour urine samples. The patients were divided into 2 groups, according to the presence of composite kidney outcomes.The study included 23 patients with diabetic nephropathy. The kidney endpoint was achieved in 34.8% (n=8) of the patients. Hypertension, duration of diabetes mellitus, creatinine level at the date of biopsy, microalbuminuria and non-albumin proteinuria were found to be independent predictors for composite kidney outcome (p=0.002, p=0.007, p=0.004, p=0.006, and p=0.001, respectively).NAP was found to be an independent risk factor for doubling the serum creatinine level from the date of biopsy, for starting hemodialysis or peritoneal dialysis, for kidney transplantation, and kidney-related death.
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