二茂铁
三苯基膦
化学
高分子化学
药物化学
组合化学
立体化学
催化作用
有机化学
物理化学
电化学
电极
作者
Jingjing Zhong,Zhao-Guo Hong,Sudi Huang,Qiongqiong Zhong,Liangliang Zhang,Shulin Zhao,Hong Liang,Fu‐Ping Huang
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:51 (47): 18054-18058
被引量:3
摘要
A triphenylphosphine coordinated Cu(I) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (˙OH) via a Fenton-like reaction induced by Cu(I) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of Fc-OD-Cu is higher than that of Ba-OD-Cu (without ferrocene moieties) and Fc-OD (without Cu(I) moieties).
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