Therapy of mitochondria-targeted hybrid nanozymes for reactive oxygen species-induced diseases

The development of enzyme mimetics that clear excess mitochondrial reactive oxidative stress (ROS) could provide effective treatment for a wide variety of diseases. Herein, nanomaterials were used to create artificial hybrid nanozymes. These nanozymes are composed of metal nanoparticle cores that act as centers of enzymatic activity and modifications for mitochondrial targeting capabilities. The artificial nanozyme possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties. In spite of low doses, it exhibits cytoprotective properties against ROS-mediated damage and significantly enhances therapeutic effects after acute spinal cord injury (SCI), acute colitis, collagen induced arthritis (CIA), and obesity. Moreover, this artificial nanozyme ensures biocompatibility. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, which will facilitate recovery from ROS-related diseases and lay the groundwork for future development of nanozyme.