生命银行
医学
BMPR2型
内科学
肺动脉高压
右心导管插入术
政治学
生物信息学
遗传学
基因
生物
骨形态发生蛋白
作者
Benjamin Woolf,James A. Perry,Charles C. Hong,Martin R. Wilkins,Mark Toshner,Dipender Gill,Stephen Burgess,Christopher J. Rhodes
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2024-03-07
卷期号:63 (4): 2302031-2302031
标识
DOI:10.1183/13993003.02031-2023
摘要
Interleukin-6 (IL-6) has been linked with the pathobiology of pulmonary arterial hypertension (PAH). IL-6 plasma levels are elevated in PAH patients and closely linked to survival (1). Both increased IL-6 activity and gene knockout influence the development of, and resistance to, pulmonary hypertension in animal models (2–4). IL-6 can repress expression of BMPR2, a gene key to PAH risk (5). Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflicts of interests: The authors declare no conflicts of interest.
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