纳米纤维
血管内皮生长因子
伤口愈合
再生(生物学)
脚手架
血管生成
表皮生长因子
皮肤修复
生长因子
血管内皮生长因子A
细胞生物学
材料科学
生物医学工程
纳米技术
化学
免疫学
医学
癌症研究
生物
生物化学
血管内皮生长因子受体
受体
作者
Ruyi Fan,Chuwei Zhang,Fēi Li,Bo Li,Alec McCarthy,Yi Zhang,Shixuan Chen,Lin Zhang
标识
DOI:10.1002/advs.202309993
摘要
Abstract To address current challenges in effectively treating large skin defects caused by trauma in clinical medicine, the fabrication, and evaluation of a novel radially aligned nanofiber scaffold (RAS) with dual growth factor gradients is presented. These aligned nanofibers and the scaffold's spatial design provide many all‐around “highways” for cell migration from the edge of the wound to the center area. Besides, the chemotaxis induced by two growth factor gradients further promotes cell migration. Incorporating epidermal growth factor (EGF) aids in the proliferation and differentiation of basal layer cells in the epidermis, augmenting the scaffold's ability to promote epidermal regeneration. Concurrently, the scaffold‐bound vascular endothelial growth factor (VEGF) recruits vascular endothelial cells at the wound's center, resulting in angiogenesis and improving blood supply and nutrient delivery, which is critical for granulation tissue regeneration. The RAS+EGF+VEGF group demonstrates superior performance in wound immune regulation, wound closure, hair follicle regeneration, and ECM deposition and remodeling compared to other groups. This study highlights the promising potential of hierarchically assembled nanofiber scaffolds with dual growth factor gradients for wound repair and tissue regeneration applications.
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