Metal-Organic Frameworks in Neural Regeneration

In recent years, significant progress in the field of neural regeneration, driven by advancements in materials science and neurobiology, has introduced metal-organic frameworks (MOFs) as a promising avenue for enhancing neural regeneration within the nervous system. This chapter provides a comprehensive exploration of MOFs in neural regeneration, encompassing their design, synthesis, applications in neural tissue engineering, and unique structural features like high surface area and tunable pore sizes. Additionally, it examines how MOFs influence cell adhesion, migration, differentiation, and serve as platforms for controlled release of therapeutic agents to promote neuroprotection, neurogenesis, and axonal growth. The chapter also critically assesses MOFs' biocompatibility, considering cytotoxicity, immunogenicity, and long-term effects in neural systems, while addressing challenges and future directions in the field, emphasizing the need for in-depth in vivo studies and harnessing MOFs' potential in clinical neural regeneration applications. In summary, this chapter highlights the emerging role of MOFs in advancing neural regeneration, offering transformative solutions and innovative approaches in the evolving landscape of regenerative medicine.Introduction