Cu-Catalyzed Cycloaddition of Aryl Azides to 1-Iodobuta-1,3-diynes: An Experimental and Quantum Chemical Study of Unusual Regiochemistry

Cu-Catalyzed azide-alkyne cycloaddition (CuAAC) in the case of 1-iodoalkynes has been known as a synthetic tool towards 5-iodo-1,2,3-triazole derivatives. We found that CuAAC of 1-iodobuta-1,3-diynes and aryl azides under CuI(PPh3)3...