小泡
细胞生物学
细胞质
生物物理学
化学
细胞外
四斯潘宁
渗透性休克
生物
生物化学
细胞
膜
基因
作者
Kiwamu Yoshikawa,Shōgo Saitō,Tetsuya Kadonosono,Masayoshi Tanaka,Mina Okochi
标识
DOI:10.1002/1873-3468.14816
摘要
Migrasomes are extracellular vesicles that form on the retraction fibers of migrating cells. In this study, we report the formation of migrasome-like vesicles enriched in tetraspanin 4 and containing cytoplasmic components in response to hypoosmotic stress. When migrating cells were subjected to hypoosmotic stress, vesicles with a size distribution of 0.5 to 2 μm formed on the retraction fibers, and vanished in a few minutes. The vesicles are rich in cholesterol, and their number was reduced when cells were pretreated with lipoprotein-deficient serum. The formation of migrasome-like vesicles upon hypoosmotic stress may provide biophysical cues regarding the cellular response to this external stimulus in cells and tissues.
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