医学
恶性肿瘤
癌症
不利影响
头颈部癌
生物信息学
HMG-CoA还原酶
放射治疗
重症监护医学
药理学
内科学
还原酶
生物
生物化学
酶
作者
Natalia Ricco,Stephen J. Kron
出处
期刊:Cancers
[MDPI AG]
日期:2023-08-03
卷期号:15 (15): 3948-3948
被引量:3
标识
DOI:10.3390/cancers15153948
摘要
Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This review focuses on their potential applications in head and neck cancer (HNC), a common malignancy for which established treatment often fails despite incurring debilitating adverse effects. Preclinical and clinical studies have suggested that statins may enhance HNC sensitivity to radiation and other conventional therapies while protecting normal tissue, but the underlying mechanisms remain poorly defined, likely involving both cholesterol-dependent and -independent effects on diverse cancer-related pathways. This review brings together recent discoveries concerning the anticancer activity of statins relevant to HNC, highlighting their anti-inflammatory activity and impacts on DNA-damage response. We also explore molecular targets and mechanisms and discuss the potential to integrate statins into conventional HNC treatment regimens to improve patient outcomes.
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